M-lab

M-Lab

Low cost stamp fabrication

M-lab

M-Lab

M-lab

M-Lab

Lab-Day 2019

M-lab

M-Lab

M Lab- Picnic to Deharje- Vikramgadh in 2020

M-lab

M-Lab

M-lab

M-Lab

Cell patterning on embedded bead substrate

M-lab

M-Lab

Cytoskeleton

M-Lab

M-lab

M-Lab

Cytoskeleton of cluster of cells

M-Lab

M-Lab focuses how different mechanical aspects of a tissue control/influence cellular behaviour and fate. The knowledge gained will help in designing efficient scaffolds for tissue engineering, cell delivery systems for stem cell based treatments and might indicate new treatment target to control diseases related to cellular migration including cancer. It will also help us to understand the role of mechanics in pattern formation, development and pathological conditions

 


Research Areas

In the field of mechanobiology, it has been very well established that mechanical properties of cellular micro-environment provides a significant contribution towards cellular behaviour. One of the major player in mechanobiology is material’s stiffness. It has been proved that, when cells are seeded on a hard substrate, they spread more and become flat as compared to soft material where they almost remain round. However, this property has been studied with sparsely seeded cells, on contrary to in-vivo where cells are not distantly apart but in close…

Application of stem cells in the field of regenerative medicine and tissue engineering is one of the most trending prospects. However, getting higher number of functional stem cells to begin with is a bottleneck. The general procedure of stem cell isolation involves extraction from tissues such as bone marrow, dental pulp, adipose tissue, umbilical cord, etc. However, the proportion of stem cells is very low in any given tissue, thus their in-vitro expansion is essential. When cultured extensively in-vitro, stem cells lose their potency and…

The cells in our body are of many different shapes. These shapes are important for the structure and function of tissue. To study the effect of cells shape on the cellular functions (for example differentiation and migration) in lab, cells are grown on proteins, printed in different shapes on flat surface (plastic or gel). The method used for printing protein on the surface using stamps is called microcontact printing.  Photolithography, a technique that employs light as a chisel to etch, is usually used to fabricate the mould for these stamps.…

Following research was done in collaboration with Prof. Dulal Panda, BSBE IITB.

Methyl-β-cyclodextrin (MCD), an established pharmacological adjuvant enhances the solubility and bioavailability of several small molecules, drugs and nano-particles. It also reduces actin filaments which is one of the cellular cytoskeletal elements. This cytoskeletal filament controls multiple cellular processes such as cell migration, division,…

Skin cells gets replenished every 24 hr to keep skin healthy. However, with skin injuries such as wounds, diabetic ulcers, and severe burns, this replacement get severely affected. To overcome this issue, various companies have generated tissue grafts which originate from cadavers or skin patches from different parts of host body. Both processes are expensive and tedious. In this research, we have shown that skin stem cells (keratinocytes) can be isolated and propagated on substrates with optimum stiffness. The given substrate stiffness not only maintains the basic…


People

  • Principal-investigator
  • M-Tech
  • PhD-Scholar
  • PostDoctoral-Researchers
  • Research-Staff
  • Alumni
Abhijit Majumder
Abhijit Majumder

abhijitm [at] iitb [dot] ac [dot] in
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Pankaj Mogha
Pankaj Mogha

biotech [dot] pankaj [at] gmail [dot] com
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Ketaki Bachal
Ketaki Bachal

ketakibachal [at] gmail [dot] com
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Shital Yadav
Shital Yadav

shitalsy011 [at] gmail [dot] com
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Rohit Joshi
Rohit Joshi

rohitjoshi013 [at] gmail [dot] com
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Nehal
Nehal Dwivedi

nehal [dot] dwivedi [at] gmail [dot] com
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Bhumi Suthar
Bhumi P Suthar

bhumimist [at] gmail [dot] com
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Akshada Khapdekar
Akshada Khapdekar

akshu251 [at] gmail [dot] com
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Pallavi Shirke
Pallavi Shirke

pushpa [dot] shirke [at] gmail [dot] com
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Shatarupa Sinha
Shatarupa Sinha

sinha [dot] shatarupa28 [at] gmail [dot] com
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Shruti Iyer
Shruti S Iyer

shrutiiyer29 [at] gmail [dot] com
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Nikita Mundhara
Nikita Mundhara

nikitamundhara [at] iitb [dot] ac [dot] in
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Ranjita Save
Ranjita Save

ran [dot] save [at] gmail [dot] com
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Darshan Shah
Darshan Shah

darshans [at] iitb [dot] ac [dot] in
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Ashwini Khaladkar
Ashwini Khaladkar

ashwinipk2050 [at] gmail [dot] com
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Mukund Srivastava
Mukund Srivastava

mukund [dot] meche [at] gmail [dot] com
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Sanjay Kureel
Sanjay Kureel

skkureel113 [at] gmail [dot] com
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Utkarsh
Utkarsh Saraswat

saraswat [dot] utk [at] gmail [dot] com
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Sourav
Sourav Mukherjee

sourav [dot] mukherjee1327 [at] gmail [dot] com
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Anyesh De
Anyesh De

anyesh17 [at] iiserb [dot] ac [dot] in
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