Topic 3 : Metabolic engineering of heterotrophic bacteria (Sugar to chemicals).

-  After the biofuel revolution, there is a need to develop robust technologies for the conversion of sugars to value-added chemicals.

-  The pathway typically involves 3-5 new genes and may additionally require knocking out of a few genes.

Topic 2 : Synthetic biology and metabolic engineering of cyanobacteria (CO2 to chemicals).

-  Cyanobacteria are photosynthetic prokaryotes.

-  We have isolated fast-growing and robust cyanobacteria from Powai lake.

-  We are developing these cyanobacteria as hosts for metabolic engineering.  This involves:

Topic 1 : Global metabolomics to identify markers for pre-diabetes and severity markers for diabetes.

- Diabetes develops over a period of 2-5 years.  Patients benefit immensely if they get a warning sign during this period.

Once developed, diabetes may result in complications.  Currently, available markers do not talk about the severity of the disease.