Pancreas on a chip to understand nanoparticle mediated drug delivery for killing of pancreatic cancer-cells

Pancreatic cancer is one of the cancers having the lowest 5-year survival rate, because of its late diagnosis and availability of only a couple of known drugs with very moderate increase in patient’s survival. Based on our earlier work, we have shown that, nanoparticle mediated delivery of existing drugs can enhance the cytotoxicity in cancer cells.

Polymer-grafted nanoparticles

Composites of polymer and nanoparticles have many property improvements compared to pure polymer.  These include improvements in mechanical strength, thermal conductivity, electrical conductivity, optical properties, and photoelectric properties.  However, the mixing of polymer with nanoparticles often poses a problem.  To over come this issue and others, there have been recent efforts toward the synthesis of polymer-grafted nanoparticles.  These new types of species show interesting phase behavior - often forming new types of self-assembled phases with new interesting properties (https://p

Film formation and anti-microbial studies of nano-composite coatings

Preventing or inhibiting the growth of micro-organisms on surfaces is of prime importance in the healthcare and textile industries. A promising strategy to overcome microbial growth involves coating the surfaces with materials that can provide resistance to microbial colonization. Inorganic nano materials and organic materials with inorganic inclusions are being widely used as anti-microbial coatings.

Zebrafish and embryo models for nanomedicine studies

Objectives: To develop zebrafish based models for understanding action of nanomedicines including Ayurvedic and Homeopathic ones. To test them by physico-chemical and biological means: in-vitro in mammalian cell culture, in-vivo in small animals and fish, fish embryos, and behavioral studies. Studies will include medicines across multiple systems of medicine and mainly experimental with some model building and simulations.

Ultrasonic atomisation and the Faraday instability - a route for drug nanoparticle synthesis: Experiments, modelling and simulations

The phenomenon of ultrasonic atomisation was first reported by Wood and Loomis nearly a century ago in 1927 [1] and since then has been extensively used for various purposes [2] like pulmonary drug delivery [3], preparation of fine powders [4], combustion of liquid fuels [5], ultrasonic spray pyrolysis [6] to name only a few. In this method of atomisation, mechanical energy transmitted from a rapidly vibrating piezoelectric crystal (in the ultrasonic regime) to a liquid layer in contact with it, causes large capillary waves to develop at the surface of the liquid.

Chemical sensor development for water contaminants and technology for their removal

Continuous monitoring of water quality parameters, like total dissolved solids, heavy metals, inorganic ions, organic pollutants an important measurement, to ascertain quality and use of a water body. This is critical for both a flowing water-stream (river, canal) or a stagnant water-pool, like a lake.

Engineering nanoparticle shape and reaction rates: Multiscale modeling, simulation and applications

Nanoparticles show new and interesting properties different from bulk materials due to their extremely small size (diameter), large specific surface area and spatial anisotropy. It is thus critical to understand the variables that control its synthesis, leading to a desired application. Control of mean nanoparticle size, particle size distribution and specially, anisotropic particle shapes - like cylindrical nanorods, is the first step in many of these applications, involving enhanced adsorption and reaction rates.