End stage renal disease (ESRD) is the complete failure of kidney functions, where kidneys can no longer remove wastes,  concentrate urine, and regulate many other important body functions. Hemodialysis is one the most effective and widely used mode to  regulate the kidney functions artificially. The hemodialyzer cartridge (disposable blood filter) is the key component of this treatment  technology and is currently imported. At the Department of Chemical Engineering, we have successfully developed an indigenous and low-cost technology for continuous pilot-scale production of hollow fiber membranes to be used in hemodialysis and built prototype  microdialyser. Our formulated special antioxidative composite polsulfone/vit E TPGS membrane material improves the performance in both separation and biocompatibility front. This will permit faster treatment, lesser side reactions and could spur novel devices like portable/wearable dialysers. Along with these we have also used the HFM technology in making a step towards bioartificial organs like bioartificial liver and bioartificial pancreas.

Bone grafts are frequently used in surgical interventions for such skeletal deficiencies and are second to blood transfusion on the list of  transplanted materials. We have developed ideal bone graft by preparing electrospun membranous 2D nano-fibers and biodegradable  3D composites as a biomimetic scaffold. The scaffolds have shown promising performance both in-vitro and in-vivo. Thus, the new  materials developed here are ready for human clinical trials and could help in fast healing of various dentistry and orthopaedics.