Microfluidics

Research groups

Pancreas on a chip to understand nanoparticle mediated drug delivery for killing of pancreatic cancer-cells

Pancreatic cancer is one of the cancers having the lowest 5-year survival rate, because of its late diagnosis and availability of only a couple of known drugs with very moderate increase in patient’s survival. Based on our earlier work, we have shown that, nanoparticle mediated delivery of existing drugs can enhance the cytotoxicity in cancer cells.

Droplet manipulation inside a microfluidic device for biological applications

Droplet microfluidics is an emerging technology in the fields of cell biology, disease diagnostics, drug discovery, etc. The versatility of droplet microfluidics lies in the ability to generate and manipulate picoliter volume droplets with a high throughput. Droplet manipulation includes fusion, fission, sorting, guiding, trapping, etc.

Biomedical Devices for resource controlled settings

An estimated 700 million Indians live in rural areas with most not having accessing to even basic medical facilities. This leads to deaths despite diseases that are curable and preventable. Around 30% of patients travel more than 30km to seek basic healthcare. Our research group has been working on compact, point-of-care blood cell counter that measures the complete blood count, which is the most basic test to asses one's health.

Flow control in microfluidic networks

Microfluidics technology has been seen to have great potential in lab-on-a-chip applications including chemical analysis and diagnostics. However, flow control in these networks requires either a pneumatic or fluidic control layer over the microfluidic layer. Recent studies have shown that integrated flow control may be achieved by introducing capacitive elements or obstacles in the flow path so that system response becomes non-linear as required for flow switching.

Chemical sensor development for water contaminants and technology for their removal

Continuous monitoring of water quality parameters, like total dissolved solids, heavy metals, inorganic ions, organic pollutants etc.is an important measurement, to ascertain quality and use of a water body. This is critical for both a flowing water-stream (river, canal) or a stagnant water-pool, like a lake.