Developing improved CHO host cells for production of monoclonal antibodies


Recombinant proteins such as monoclonal antibodies form a major part of the therapeutics used to treat various diseases. Mammalian cells, specifically CHO cells, are preferred as hosts for the production of recombinant therapeutics due to their ability to post-translationally modify and secrete functionally active proteins. In this project, we aim to develop a CHO host cell that is engineered to enhance its protein secretion capacity to improve the productivity of recombinant proteins. 

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