Understanding the role of Substrate Rheology on Cell Fate


In this project the candidate is expected to prepare various materials, estimates their rheological properties, and then explore the effect of rheological properties on cell fate in the context of stem cell differentiation and cancer. This project will supervised jointly by Prof. Jyoti Seth and Prof. Abhijit Majumder. To get a flavor of the work, interested candidate may look at the following papers:

1. "“Viscotaxis”-directed migration of mesenchymal stem cells in response to loss modulus gradient" 2021 Acta Biomaterialia

2. Viscoelastic substrate decouples cellular traction force from other related phenotypes, 2021, BBRC

3. Substrate loss modulus promotes the differentiation of SHSY-5Y neuroblastoma cells 2020 Materialia.


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