Brain Cancer Tumor on Chip
Understanding tumor growth on dish has always been a challenge for its complex nature. It involves cell to cell contact between multiple cell types, complex tissue 3D architecture, tissue rigidity, designing nearby blood vessels etc. In the proposed work, we plan to develop “Brain Cancer Tumor on Chip.” The project will have multiple parts such as developing blood vessels on chip, developing brain tumor micro-environment, and then finally assembling all the parts together. The model developed will help us in testing drugs for their ability to cross blood-brain barrier (https://en.wikipedia.org/wiki/Blood%E2%80%93brain_barrier).
The work will involve microfluidics (including simulation), micro-fabrication, and cell culture.
No prior experience in cell biology is needed. However, a keen interest in biology is absolute must.