Genome Scale Flux Balance Metabolic Models for recombinant CHO cells

A bottleneck in improving productivity of recombinant biotherapeutics from mammalian cultures is the accumulation of inhibitory by-products like lactic acid. The objective of the present work is to use flux-balance analysis methods on a genome scale metabolic model of CHO cells to devise ways to control lactate switch in a recombinant cell line producing the receptor binding domain of the SARS-COV2 virus. 

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