Venkatesh Lab
Osmoregulation in S. cerivisae
Several negative feedback loops have been identified in the osmoadaptation system in yeast. However, the precise location of the integrating process in the osmoadaptation system which includes signalling, gene regulation, metabolism and biophysical modules is unclear. To address this issue, we developed a reduced model which captures various experimental observations of the osmoadaptation behaviour of wild type and mutant strains.
Dynamic simulations and steady state analysis suggested that known information about the osmoadaptation system of budding yeast does not necessarily give a perfect integrating process through the known feedback loops of Hog1PP. On the other hand, regulation of glycerol synthesising enzyme degradation can result in a near integrating process leading to a near-perfect adaptation.
Network Analysis in Biological Systems
- Signaling Networks
- Genetic Networks
- Metabolic Networks
PUBLICATIONS
Analysis of osmoadaptation system in budding yeast suggests that regulated degradation of glycerol synthesis enzyme is key to near-perfect adaptation
AK Patel, S Bhartiya, KV Venkatesh, Systems and Synthetic Biology, 1-14, 2013
A Model-based Study Delineating the Roles of the Two Signaling Branches of Saccharomyces cerevisiae, Sho1 and Sln1, during Adaptation to Osmotic Stress
J. H. Parmar, Sharad Bhartiya & K. V. Venkatesh, Physical Biology, 6(3), 2009.