Venkatesh Lab

Research Highlights

Bacterial Metabolism

Understanding bacterial metabolism at transcriptomics, genomics, proteomics and metabolomics levels and help bridge the genotype to phenotype gap

Human Metabolic Disease Modeling

Building whole body mechanistic models in humans to understand metabolic diseases and help in the identification of potential drug targets.

Network Analysis of Biological Systems

Genetic and signaling network analysis of various biological systems such as tryptophan regulation in bacteria, GAL system in yeast. and Calcium oscillations in human cells.

About Us

Welcome to Venkatesh Lab at Department of Chemical Enginnering.

IIT Bombay 

Given the explosion and availability of biological data, computational analysis in Biological sciences has become a necessity. There is hope that this will increase applications in biotechnology, resulting in a strong need for quantification of biological systems. Biological systems are highly interconnected and hierarchical with unique structures.

Our main focus lies in interfacing engineering principles with biology and medicine. We have applied engineering design principles to biological systems to obtain insights into its evolution, operation and regulation by developing novel theoretical methodologies to analyze biological networks at genetic, signaling and metabolic levels. The design principles inherent in living systems have been experimentally demonstrated in our lab. Our group was one of the first to reverse engineer the design prevailing in a microorganism to a physical system thus demonstrating the relevance of using engineering principles in both living and non-living systems.

Recent Publications

  • Shekhar Mishra, Pramod R Somvanshi and K.V.Venkatesh, " Control of cholesterol homeostasis by entero- hepatic bile transport–the role of feedback mechanisms" RSC Advances, 2014, 4, 58964Steady State Analysis of Genetic Regulatory Network incorporating underlying Molecular Mechanisms for Anaerobic Metabolism in Escherichia coli, Sumana Srinivasan and K. V. Venkatesh*,Mol. BioSyst., 2014,10, 562-575

  • Steady state analysis of the genetic regulatory network incorporating underlying molecular mechanisms for anaerobic metabolism in Escherichia coli, S Srinivasan, KV Venkatesh, Molecular BioSystems, 2014.

  • Optical Control Demonstrates Switch-Like PIP3 Dynamics Underlying The Initiation Of Immune Cell Migration. Ajith Karunarathne, Lopamudra Giri, Anilkumar K. Patel, Kareenhalli V. Venkatesh, and N. Gautam, Proceedings of National Academy of Sciences 2013 110 (17) E1575-E1583.