Venkatesh Lab

Osmoadaptation analysis in S. cerivisae

 

Molecular and physiological details of osmoadaptation in yeast Saccharomyces cerevisiae are well characterized. It is well known that a cell, upon osmotic shock, delays its growth, produces a compatible solute like glycerol in yeast to maintain the osmotic equilibrium. Many genes are regulated by the hyperosmolarity glycerol (HOG) singling pathway, some of which in turn control the carbon flux in the glycolytic pathway for glycerol synthesis and reduced growth. The whole process of survival of cells under hyperosmotic stress is controlled at multiple levels in signaling and metabolic pathways. To better understand the multi-level regulations in yeast to osmotic shock, a mathematical model is formulated which integrates the growth and the osmoadaptation process.

 

Publications

 

Quantification of metabolism in Saccharomyces cerevisiae under hyper osmotic condition using Elementary mode analysis.

Jignesh Parmar, Sharad Bhartiya and K. V. Venkatesh, Journal of Industrial Microbiology and Biotechnology, 2011

 

Characterization of the Adaptive Response and Growth upon Hyperosmotic Shock in Saccharomyces cerevisiae

Jignesh Parmar, Sharad Bhartiya and K. V. Venkatesh, Molecular Biosystems, 2011