Corynebacterium glutamicum, a soil bacterium, is used to produce amino acids such as lysine and glutamate. C. glutamicum is often exposed to osmolality changes in its medium, and the bacterium has therefore evolved several adaptive response mechanisms to overcome them. We have quantified the metabolic response of C. glutamicum under osmotic stress using elementary mode analysis (EMA). Further, we have obtained the optimal phenotypic space for the synthesis of lysine and formation of biomass.
Lysine overproducing Corynebacterium glutamicum is characterized by a robust linear combination of two optimal phenotypic states
M Rajvanshi, K Gayen, KV Venkatesh, Systems and synthetic biology 7 (1-2), 51-62, 2013.
Phenotypic Characterization of Corynebacterium glutamicum Using Elementary Modes towards Synthesis of Amino Acids
Rajvanshi, M., K.V. Venkatesh, , Systems and Synthetic Biology, 2011
Phenotypic characterization of Corynebacterium glutamicum under osmotic stress conditions using elementary mode analysis, Rajvanshi, M., K.V.Venkatesh, Journal of Industrial Microbiology and Biotechnology , pp. 1-13, 2010.
Phenotypic Characterization of Corynebacterium glutamicum Using Elementary Modes towards Synthesis of Amino Acids,
Devesh Radhakrishnan, Meghna Rajvanshi, K. V. Venkatesh, Journal of Systems and Synthetic Biology, 2010
Quantification of cell size distribution as applied to the growth of Corynebacterium glutamicum
Kalyan Gayen and K V Venkatesh, Microbiological Research, 163, 586-593, 2008
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A phenomenological model to represent the kinetics of growth by Corynebacterium glutamicum for lysine production
Kalyan Gayen and K. V. Venkatesh, Journal of Industrial Microbiology and Biotechnology, 34, 363-372, 2007.
Evaluation of fluxes of elementary modes through linear programming: Applied to Corynebacterium glutamicum
Kalyan Gayen and K.V. Venkatesh, Understanding and exploiting Systems Biology in Biomedicine and Bioprocesses, Editor: Arturo Manjon, 211-222, 2007.
Analysis of optimal phenotypic space using elementary modes as applied to Corynebacterium glutamicum,
Kalyan Gayen and K.V. Venkatesh, BMC Bioinformatics, 7,445, 2006.