State estimation

Plantwide real time optimization, control and estimation of a solar thermal power plant

This work will deal with plantwide simulation studies for real time optimization, control and estimation using a dynamic model of a solar thermal power plant. The model was developed by an earlier PhD student and mimicks an actual 1 MW hybrid solar thermal power plant designed, commissioned and installed by a team from IIT Bombay. 

Apoptosis modulation in cancer cells

Tumor necrosis factor alpha (TNFa), a pleiotropic cytokine capable of exhibiting pro-survival, apoptosis, or necrotic phenotypes, is implicated in several cancers. Understanding the underlying mechanism that governs a cell’s decision to apoptotic phenotypic response, a desired outcome, can help obtain insights on how signal flow to cell-death can be modulated. This leads to a question as to what intracellular interventional strategies could be employed to manipulate signal flow to cell-death state.