Tumor necrosis factor alpha (TNFa), a pleiotropic cytokine capable of exhibiting pro-survival, apoptosis, or necrotic phenotypes, is implicated in several cancers. Understanding the underlying mechanism that governs a cell’s decision to apoptotic phenotypic response, a desired outcome, can help obtain insights on how signal flow to cell-death can be modulated. This leads to a question as to what intracellular interventional strategies could be employed to manipulate signal flow to cell-death state.