Reaction network

Combined theory and experimental study of controlled metal (electro)dissolution for water disinfection

Metal dissolution is often used to kill bacteria in water. Upon dissolving the metal forms ions which can effectively kill E. coli. There is a significant need to understand the dissolution mechanism and design/control the process. The overall dissolution rates depend primarily on factors such as the overpotential, electrode surface area, temperature, and pH.

Orchestration of cancer cell response

Tumor necrosis factor-alpha (TNFa), an inflammatory cytokine present in large quantities in a tumor microenvironment, is strongly implicated in various cancer cell responses.  The objective of this project is to understand the orchestration of response of cancer cells exposed to a drug cocktail. The project will involve static and discrete dynamical modelling of activated TNFa signalling network consisting of biochemical reactions, curated in-house.

Apoptosis modulation in cancer cells

Tumor necrosis factor alpha (TNFa), a pleiotropic cytokine capable of exhibiting pro-survival, apoptosis, or necrotic phenotypes, is implicated in several cancers. Understanding the underlying mechanism that governs a cell’s decision to apoptotic phenotypic response, a desired outcome, can help obtain insights on how signal flow to cell-death can be modulated. This leads to a question as to what intracellular interventional strategies could be employed to manipulate signal flow to cell-death state.