Reaction network

Metal dissolution is often used to kill bacteria in water. Upon dissolving the metal forms ions which can effectively kill E. coli. There is a significant need to understand the dissolution mechanism and design/control the process. The overall dissolution rates depend primarily on factors such as the overpotential, electrode surface area, temperature, and pH.

Tumor necrosis factor-alpha (TNFa), an inflammatory cytokine present in large quantities in a tumor microenvironment, is strongly implicated in various cancer cell responses.  The objective of this project is to understand the orchestration of response of cancer cells exposed to a drug cocktail. The project will involve static and discrete dynamical modelling of activated TNFa signalling network consisting of biochemical reactions, curated in-house.

Tumor necrosis factor alpha (TNFa), a pleiotropic cytokine capable of exhibiting pro-survival, apoptosis, or necrotic phenotypes, is implicated in several cancers. Understanding the underlying mechanism that governs a cell’s decision to apoptotic phenotypic response, a desired outcome, can help obtain insights on how signal flow to cell-death can be modulated. This leads to a question as to what intracellular interventional strategies could be employed to manipulate signal flow to cell-death state.