Numerical analysis of electroporation of cells and vesicles with potential use in anti-cancer therapies
The administration of anti-cancer drugs such as Cisplatin and Bleomycin is known to be significantly enhanced when used in conjunction with electroporation. Electroporation involves punching of holes of the size of few 10s of nanometers into bilayer membranes to put across polar drugs or nanoparticles.
The project would involve consistent formulation for cell electroporation, simultaneously solving for deformation and poration using the Boundary integral method.
The relevant references are:
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S Das, M Jaeger, M Leonetti, RM Thaokar, PG Chen, Effect of pulse width on the dynamics of a deflated vesicle in unipolar and bipolar pulsed electric fields, Physics of Fluids 33 (8), 081905, 2021
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M Maoyafikuddin, RM Thaokar, Effect of the Waveform of the Pulsed Electric Field on the Cylindrical Deformation of Uncharged Giant Unilamellar Vesicles Langmuir 39 (28), 9660-9670 2023