Liver Organoid on Chip

The human liver plays a key role in drug metabolism and detoxification. People who consume large amounts of medication or alcohol typically have impaired liver function. The creation of a liver organoid on a chip would greatly assist in drug development to assess the hepatotoxic level of a potential drug.

This project aims to build a liver organoid on-chip and test its properties. The student will use a microfabricated 3D spheroid making device developed in the lab and will form liver spheroids. The student will study the effect of standard drugs on these spheroids.