Deepak Gupta

Education

M.Tech.+Ph.D. (Dual Degree) (Chemical Engineering), Indian Institute of Technology Bombay, India (Pursuing)

B.Tech. (Chemical Engineering), Indian Institute of Technology (BHU) Varanasi, India, 2014

ORCHID iD: https://orcid.org/0000-0003-0069-7488

Research Topic: Development of multi-functional low-cost scaffold for bone reconstruction

Research Summary

Human bone is a highly complex dynamic tissue and defect in bone requires a multi-functional bone-like scaffold for which further research is needed. My research is aimed at fabricating synthetic bone grafts which are biocompatible, bioresorbable, osteoconductive, and osteoinductive, and mimic mechanical strength, porosity, and internal architecture of human bone. The main aspect of research work includes the selection of biomaterials, developing customized 3D printers, building bone-like mesh design with a programming language, a combination of different scaffold-fabrication techniques, testing of the grafts with osteosarcoma cells and human umbilical cord mesenchymal stem cells in-vitro, and in-vivo in a rabbit model. The aim is to develop an ideal bone graft to regenerate lost bone due to trauma, disease, or accident thus benefitting the society to a large extent.

Keywords: Bone tissue engineering; bone graft; scaffold; bone regeneration; segmental defect; ceramics; 3D printing; lyophilization; hydrogel; cryogenic; mesh; Python; gradient porosity; osteoconductive; CT scan; maxillofacial; periodontal; orthopaedics; crosslink; bioresorbable; patient specific.

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