Network biology

Orchestration of cancer cell response

Tumor necrosis factor-alpha (TNFa), an inflammatory cytokine present in large quantities in a tumor microenvironment, is strongly implicated in various cancer cell responses.  The objective of this project is to understand the orchestration of response of cancer cells exposed to a drug cocktail. The project will involve static and discrete dynamical modelling of activated TNFa signalling network consisting of biochemical reactions, curated in-house.

Phenotype switching during TNFa signaling

Tumor necrosis factor alpha (TNFa), a pleiotropic cytokine capable of exhibiting pro-survival, apoptosis, or necrotic phenotypes, is implicated in several cancers. Signal flow leading to these multitude of context-specific responses is orchestrated by underlying molecular network consisting of nodes such as proteins, genes connected by interactions between them. This leads to a question as to what are the topological properties of the network that dictate the context-specific responses and how to modulate these to favour a desired phenotype.