Most of the cells in our body go to a non-proliferative state after a certain numbers of cell division. This cellular state is known as replicative senescence (RS). While RS has been implicated in aging, it is also a tool formed by nature against cancer. Hence, it is important to study this cellular state in details. Our lab has shown that RS can be delayed by manipulating the mechanical signals or by condensing chromatin using chemical signals. In this project, the student will explore the crosstalk between these two signaling cues in human mesenchymal stem cells.
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