Microfluidics for biological studies

Microfluidics systems for droplet manipulation and anti-susceptibility test

The project aims to develop microfluidic droplet systems for biological research applications such as Antimicrobial susceptibility tests. It involves studying the hydrodynamics of droplet guiding and trapping using passive droplet manipulation methods and performing biological experiments using microfluidic droplet techniques. Current research activities focus on three key areas – (1) developing a droplet-based microfluidic assay for antimicrobial susceptibility tests on bacteria against common antibiotics, (2) investigation of the fundamental mechanism of droplet trapping in a microfluidic surface energy well-using experiments and simulations, (3) understanding the effect of external flow on droplet guiding using experiments and simulations.

Microfluidics based sorting of microparticle mixtures

Sorting of microparticles is an essential component in numerous areas such as industrial, environmental, and biomedical applications, to name a few. In this work we combine pillar-based sorting mechanism with hydrodynamics inside a microfluidics device to develop a ratain-and-release strategy to efficiently sort 2 and 3 particle mixtures across a range of particle ratios.

Publications:

Chandna, P., & Gundabala, V. Pillar based microfluidic approach to sorting of microparticle mixtures at various particle ratios (Under Review)