Start
Jan 27, 2012 - 17:00
End
Jan 27, 2012 - 18:00
Venue
Room 118 (Creativity Hall Ground Floor) Chemical Engineering
Event Type
Speaker
Rajesh N. Davé Distinguished Professor of Chemical Biological and Pharmaceutical Engineering NJIT Site-Leader NSF-ERC on Structured Organic Particulate Systems New Jersey Institute of Technology Newark NJ USA.
Title
Particle Engineering for Pharmaceutical Applications
Abstract: An overview is presented of the research work on creation of advanced particulate materials through engineering of particles with applications to pharmaceutical bio energetic and specialty chemical materials. With respect to pharmaceutical applications the emphasis is on a more effective utilization of the unique properties of nano and sub-micron particles through structuring/engineering of the particulates with an ultimate aim of simplifying the manufacturing processes as well as formulations. In this talk we will also discuss the particle engineering strategy for handling both low and high dosage scenarios for poorly water soluble active pharmaceutical ingredient (API) based formulations. The presented techniques are also naturally suited to those APIs which are not necessarily poorly water-soluble. In all cases the emphasis is on scalable methods that are based on sound understanding of materials and processes and help improve the quality of the products while simplifying formulations. The presentations will also include the topic of improvements and characterization and modeling of flow and other important properties. Particle contact modeling to develop predictive methodologies is reviewed starting from classical Rumpf single asperity model to some of our advanced models where the influence of material properties surface area coverage and spatial and size distribution of guest particles is considered. A simplified modeling approach is presented that allows for predicting the bulk performance that requires only small quantities of powders. Finally 2-D phase-maps are developed based on key bulk powder properties to help make manufacturing decisions regarding the formulation strategy for solid pharmaceutical dosages.About the Speaker: Dr. Rajesh N. Davé received the B. Tech. degree in Mechanical Engineering from Indian Institute of Technology Bombay in 1978 and the M.S. and Ph.D. degrees In Mechanical Engineering from Utah State University in 1981 and 1983 respectively. He is currently a Distinguished Professor in the Department of Chemical Biological and Pharmaceutical Engineering at New Jersey Institute of Technology. He is also the Site-Leader Thrust Leader and a Test-bed Leader National Science Foundation Engineering Research Center on Structured Organic Particulate Systems (NSF ERC-SOPS) a Rutgers (lead) Purdue NJIT and UPRM partnership. He is the founding Director of New Jersey Center for Engineered Particulates an R&D Excellence Center engaged in research for applications such as pharmaceutical food electronic and energetic materials. His research has been supported through grants from federal state and industrial awards totaling about $16 Million as a Principal or Co-Principal Investigator without including the $35M NSF ERC-SOPS award. His research contributions are in two main areas Particle Technology/Engineered Particulates and Fuzzy Pattern Recognition. His main research interests in Engineered Particulates include: synthesis of nano-particles and engineering of structured particle composites; modeling and development of novel techniques for dry particle coating film-coated particles granules and engineered particulates; nano-particle mixing and nano-particle fluidization; powder flow and particle-particle interactions/cohesion; and DEM simulations. He has graduated 22 doctoral students of which five are currently in US academic positions. Eight of his past postdoctoral advisees are in academic positions. At present he is supervising eight doctoral students and several post-doctoral research associates. He is the recipient of awards and honors such as: AAPS Arden Conference presentation on Poor Bio-Availability Drugs June 12-13 2010 China; Delivery of the Leslie J. Ford Lecture: Dry Particle Coating – Synthesis and Characterization of Engineered Particulates with Tailored Properties at Particle Technology UK Forum IV The University of Leeds Leeds UK April 11 2002; K. S. Fu Award from North American Fuzzy Information Processing Society (NAFIPS) June 1999; Excellence in Research Award (Newark College of Engineering) NJIT September 2008; Designation as NJIT Master Teacher September 2008; Harlan Perlis Award for Research NJIT 2001; Van Houten Award for Teaching Excellence NJIT 2004.