Prof. Sandip Kar's Talk

Jan 19, 2017 - 17:00

Jan 19, 2017 - 18:00

Rm. No. 118 Ground floor Chemical Engg. Dept.

Seminars

Prof. Sandip Kar Department of Chemistry IIT Bombay

Abstract: Neural stem cells (NSC’s) often give rise to mixed population of cells during differentiation. However the dynamical origin of these mixed states is poorly understood. In this article our mathematical modeling study demonstrates that the bone morphogenetic protein 2 (BMP2) driven differential differentiation dynamics of NSC’s in central and peripheral nervous systems essentially function through two distinct bi-stable switches that are mutually interconnected. Stochastic simulations of the model reveal that the mixed population originates due to the existence of these bi-stable switching regulations while the maintenance of such mixed states depends on the level of stochastic fluctuations of the system. Importantly the model predicts that by individually altering the expression level of key regulatory proteins the NSC’s can be converted entirely to a preferred phenotype for BMP2 doses that earlier resulted into mixed population. Our findings show that efficient neuronal regeneration can be achieved by systematically maneuvering the differentiation dynamics.Bio: Prof. Sandip Kar received his BSc & MSc in Chemistry from University of Calcutta and his PhD in Chemistry from Jadavpur University in 2006. He has been a Lecturer in Bhairab Ganguly College Kolkata (2005-2007) an NIH Postdoctoral Associate at Virginia Polytechnic State University (2007-2010) and a Senior Postdoctoral Associate at German Cancer Research Center Heidelberg. He joined the Department of Chemistry at IIT Bombay as an Assistant Professor in 2013. His research interests include systems biology of signal transduction computational Biology cell cycle stochastic modeling nonlinear dynamics bifurcation theory and pattern formation. Note: Attendance is mandatory for those enrolled in CL 704/702.