Start
Feb 27, 2009 - 16:00
End
Feb 27, 2009 - 18:00
Venue
Creativity Hall
Event Type
Speaker
Chris Macosko
Title
Polymer Protected Nanoparticles for Drug Delivery
The large surface area of nanoparticles can greatly increase the issolution rate of hydrophobic drugs. Moreover nanoscale carriers can inhibit the uptake of drug particles by the reticuloendothelial system during circulation permitting enough time for particles to localize in the leaky vasculature of tumors. We use impingement mixing and high supersaturating to create 100 nm particles via rapid precipitation. Particles are protected via block copolymers which co precipitate or are formed by fast coupling reaction during mixing. Formation of block copolymer-protected nanoparticles via reactive impingement mixing Z.X. Zhu J.L. Anacker S.X. Ji T.R. Hoye C.W. Macosko and R.K. Prud'homme Langmuir 2007 23(21) 10499-10504. )About the Speaker: Chris Macosko is Director of the Industrial Partnership for Research in Interfacial and Materials Engineering and Professor of Chemical Engineering and Materials Science at the University of Minnesota and a member of the National Academy of Engineering. He received his B.S. from Carnegie Mellon M.Sc. from Imperial College London and Ph.D. from Princeton. He has advised nearly 100 M.S. and Ph.D. students with whom he has published over 400 papers in rheology and polymer processing particularly processing with reaction such as reaction injection molding polyurethane foam crosslinking and reactive compatibilization of polymer blends. He helped to found Rheometric Scientific now part of TA Instruments and a leading producer of rheological instruments. His rheology textbook "Rheology Principles Measurements and Applications” (Wiley 1994) is widely used.