Start
Feb 09, 2016 - 17:00
End
Feb 09, 2016 - 18:00
Venue
Room 240 Chemical Engineering
Event Type
Speaker
Prof. K.D.P. NIGAM Department of Chemical Engineering IIT Delhi.
Title
COILED FLOW INVERTER: A NOVEL DEVICE
Abstract: Development of microscale equipment is mainly focused on reaction mixing and heat transfer; however for implementation in the process industry also separation is required. In particular equipment is missing that suits (i) the integration in a full-flow chain (ii) and production capacities of kilo- and pilot-labs in industry which amounts to product- and solvent flows of 1-10 kg/day and 10-100 l/day. Our device COILED FLOW INVERTER (CFI) which enhances mixing by inverting the flow due to 90 degree bend was recently tested for immiscible Liquid-liquid extraction performance at TU Eindhoven with model systems given by European Federation of Chemical Engineering of acetone-water-toluene and acetone-water-butyl-acetate. Partition coefficient were calculated and compared with the value at thermodynamic equilibrium. The performance of CFI device was further tested for metal extraction which is significant for removal of metal catalyst from the product especially for pharmaceutical substances. Copper scavenging experiments were performed using chelating agents with the initial setup. The use of different types of copper catalysts and metal scavengers were investigated together with variation of metal scavenger concentration and pH. Such analysis allowed achieving excellent extraction efficiency up to 99% enabling to meet the limit for APIs of 15 ppm in single stage of separation. CFI was used in our own department for continuous refolding of granulocyte colony stimulating factor (GCSF) a biotech therapeutic product. The performance of the continuous refolding protocol has been compared with an optimized batch refolding protocol. It has been demonstrated that enhanced mixing allows for operation at higher protein concentrations (0.38 mg/ml as compared to 0.19 mg/ml in batch) and results in comparable purity (84% vs. 83% in batch) thereby resulting in a significant reduction of costs related to downstream purification. Our developed COILED FLOW INVERTER device has been successfully demonstrated by other internationally recognised schools for its application in microreactor technology such as extraction polymerization and biotechnology. I am encouraged to share our COILED FLOW INVERTER innovation at IIT Bombay with a view to further explore the possibility of its application to different areas.Speaker Biography: Prof. Krishna Nigam is on the faculty of Chemical Engineering Indian Institute of Technology Delhi from year 1976. Professor Nigam has published about 140 research papers in peer reviewed International Journals which have received more than 2964 citations with h index of 31. His research work has been widely acclaimed and referred in prestigious journals such as Proceedings of Royal Society London Journal of Fluid Mechanics and Perry’s Hand Book etc. In particular he has made long lasting contributions to the analysis and design of Multiphase Reactors. The First Hydrocracker in India has been designed and commissioned in December 2011 based on joint efforts of his group at I.I.T. Delhi the user industry Indian Oil Corporation and the process engineering company Engineers India Limited. He has been visiting Professor in many international schools in France Germany Australia UK USA China South Korea and Mexico. He is also Adjunct Professor at Concordia University Montreal Canada (2009-2012). He is on the Editorial Board of many Elsevier Journals e.g. Chemical Engineering Research and Design Chemical Engineering and Processing Education for Chemical Engineer and Guest Editor for special issue of Chemical Engineering Science (2007 2011 & 2016). Recently he has been invited to join the International Advisory Panel of Chemical Engineering Science (2012-2018). Industrial & Engineering Chemistry Research (ACS Publication) in recognition of his contributions to Chemical Engineering has brought out Festschrift issue in his honor 51(4) 1435-2178 (2012). Recently he has been awarded the HUMBOLDT RESEARCH AWARD of Germany for the year 2011 a rare distinction making him the 1st Indian Chemical Engineer recipient of the prestigious award since its inception in 1982. Prof. Nigam served as Independent Director at National Fertilizers limited (2003-2006) and on the Board of Engineers India limited (2010-2013). Member of the Scientific Advisory Committee MoPNG GOI (2001-2003) Council member for All India Council for Technical Education (1998-2001) Council constituted by MHRD. He was a member of RAC of EIL & IOC (R&D). Member Accreditation Board of European Process Intensification Centre (EU) (March 2011) Member Working Party on Education of the European Federation of Chemical Engineers (EU) Member Innovation Council for the Fertilizer Sector Ministry of Chemical and Fertilizers GOI (2010-2020).