Every year, millions of patients suffer loss or failure of an organ or tissue as a result of accidents or disease. Tissue or organ transplantation is a commonly accepted norm under these circumstances. However, constant shortage of donor tissue and organ transplants coupled with high morbidity and mortality has spurred great interest for lab grown bioengineered tissues/organs as promising substitute. Our laboratory at IIT Guwahati specifically focuses on recreating these functional tissues, organs and implants at an affordable cost using naturally derived biodegradable biomaterials i.e. Indian endemic silk in combination with stem cells. We have developed methods using conventional and latest 3D bioprinting techniques to intricately mimic the architecture of organs/tissues in great details in an attempt to understand the underlying cell-material crosstalk and its role in tissue regeneration. As an outcome of our research endeavor at IITG, we have developed a number of affordable prototypes which are in various phases of animal/clinical validation. These include smart wound dressings for diabetic foot ulcers, skin grafts for burn injuries, vascular grafts for by-pass surgery, vascularised bone grafts as orthopaedic implants, beating cardiac patch for myocardial infarction, bioartificial pancreas releasing insulin for type-1 diabetes, 3D printed intervertebral disc and knee meniscus as orthopaedic grafts and minimally invasive anti-cancer drug eluting injectable gels for cancer treatment. Similarly, we have developed multiple in vitro human disease models which can contribute to Industry in high throughput drug screening and drug development.
Please find attached PDF for Prof. Biman Mandal's bio.