Start
Feb 27, 2009 - 16:00
End
Feb 27, 2009 - 17:00
Venue
Creativity Hall (Room 118) Chemical Engineering
Event Type
Speaker
Chris Macosko Professor of Chemical Engineering and Materials Science and Director of IPRIME the Industrial Partnership for Research in Interfacial and Materials Engineering at the University of Minnesota 421 Washington Ave. Minnesota MN 55455
Title
Polymer Protected Nanoparticles for Drug Delivery
The large surface area of nanoparticles can greatly increase the dissolution rate of hydrophobic drugs. Moreover nanoscale carriers can inhibit the uptake of drug particles by the reticuloendothelial system during circulation permitting enough time for particles to localize in the leaky vasculature of tumors. We use impingement mixing and high supersaturating to create 100 nm particles via rapid precipitation. Particles are protected via block copolymers which co precipitate or are formed by fast coupling reaction during mixing. Formation of block copolymer-protected nanoparticles via reactive impingement mixing Z.X. Zhu J.L. Anacker S.X. Ji T.R. Hoye C.W. Macosko and R.K. Prud'homme Langmuir 2007 23(21) 10499-10504. )