Start
Mar 10, 2016 - 17:00
End
Mar 10, 2016 - 18:00
Venue
Room 118 Department of Chemical Engineering
Event Type
Speaker
Kamendra P Sharma Department of Chemistry IITB
Title
Protein-Polymer Surfactant based Novel Hybrid Materials
Abstract: In my talk I will show my work related to the development of a new class of protein-based functional and dynamic nano-conjugated systems based on the molecular integration of structurally and functionally compatible polymer surfactants. I will show how the accessibility of reactive amino acid side chains present on the surface of globular proteins provides a spatially organized chemical platform for integrating hybrid components that can then be used to tune various biomaterial properties via site-specific surface functionalization. Specifically I will present my recent work on the synthesis and characterization of single-component stoichiometric protein-polymer surfactant conjugates that melt at ambient temperatures to form solvent-free liquids with protein concentrations as high as 20-25 wt.%.1 2 These novel protein biofluids offer remarkable benefits over aqueous protein dispersions including exceptionally high concentrations of protein molecules remarkable levels of thermal stability (half denaturation temperatures of around 160 °C) persistent protein dynamics and sustained biological functions. For example reversible redox transitions have been demonstrated in solvent-free myoglobin melts 1 2 and enzyme activity reported in solvent-free liquid lipases.3 Working on solvent-free liquid myoglobin and lipase I also developed an experimental methodology that resulted in the first known examples of enzymatically active self-standing hydrogel films obtained from the hierarchical assembly of protein-polymer surfactant bio-conjugates.4 This work represented the first example of metamaterial like behaviour obtained from protein based films.5 1. Sharma K. P.; Mann S. et al. J. Am. Chem. Soc. 2013 135 18311. 2. Sharma K. P.; Mann S. et al. J. Phys. Chem. B 2014 118 (39) 11573-11580. 3. Brogan A.P.S.; Sharma K. P.; and Mann S. Nat. Commun. 2014; DOI: 10.1038/ncomms6058. 4. Sharma K. P.; Mann S. et al. Adv. Mater. 2013 25 2005. 5. Sharma K. P.; Mann S. et al. Adv. Mater. 2015 DOI:10.1002/adma.201504740About the speaker: Prof. Kamendra Sharma is Assistant Professor at the Department of Chemistry IITB. He joined the institute in 2015. 1) Post-Doc 2011-2015: University of Bristol Bristol United Knigdom. Supervisor: Prof. Stephen Mann FRS 2) Ph.D. Thesis: 2005-2011: National Chemical Laboratory Pune Supervisor: Dr. K. Guruswamy Thesis title: Organization of Nanoparticles and Polymers in Surfactant Liquid Crystalline Mesophases Academic Credentials and Awards Received: Leverhulme Early Career Fellowship Leverhulme Trust London. Shah-Schulman Award for the best Ph.D. thesis in the area of Colloid and Interface Science by the Indian Institute of Engineers (2012). Joshi-Sivaram award for the Best Publication in Polymer Science and Organic-Inorganic hybrid Materials with highest impact factor (2011). “Best Ph.D. Thesis: Keerthi Sangoram award” on National Science Day held at NCL Pune India (2011).