Abstract:
Stem cell technology has emerged as a revolutionary force in healthcare, promising groundbreaking advancements in regenerative medicine, disease treatment, and personalized therapies. The versatility of stem cells, capable of differentiating into various cell types, offers unparalleled potential for tissue regeneration and organ replacement. Their regenerative properties enable the repair of damaged tissues, paving the way for effective treatments for degenerative diseases. Furthermore, the integration of stem cell technology with other cutting-edge approaches, such as 3D bioprinting and organoid development offers novel avenues in regenerative medicine. 3D bioprinting enables the fabrication of intricate three-dimensional tissue constructs, providing a platform for the development of functional organs for transplantation. Organoids, miniaturized and simplified versions of organs grown in vitro, serve as invaluable models for studying diseases and testing therapeutic interventions. Stem cells play a pivotal role in both these technologies, serving as the building blocks for engineered tissues and organoids, thereby revolutionizing transplantation procedures and accelerating drug discovery efforts. Specifically the Mesenchymal stem cells (MSCs) have gained significant attention as they are adult stem cells & pose lesser ethical concerns for isolation. Not just the cells, but their derivates also have gained significant importance in the field of regenerative medicine. Therapeutic prospects of extracellular vesicles secreted from MSCs & also their organelles, including mitochondria, have been explored for their remedial advantages. These integrations & explorations have not only enhanced our understanding of stem cell biology but have also paved the way for more sophisticated and clinically relevant applications. This comprehensive exploration underscores the transformative potential of stem cell technology in reshaping the landscape of modern healthcare. As our understanding of stem cell biology deepens and innovative technologies continue to emerge, the future holds the promise of novel and effective treatments for diseases that have long eluded medical solutions. The ethical considerations, coupled with groundbreaking scientific advancements, are propelling stem cell research into a new era, where the boundaries of what is medically possible are continually expanding.
Keywords:
Stem Cells, Tissue Engineering, Extracellular Vesicles, Regenerative Medicine,3D Bioprinting
Speaker Bio:
- Completed her Ph.D. from All India Institute of Medical Sciences, New Delhi in 1996.
- Initiated basic research using adult, embryonic, and Induced Pluripotent stem cells for a better understanding of Stem cell biology and drug discovery to strengthen the pre-clinical and clinical research.
- Established a Good Manufacturing Practices (GMP) Facility in accordance with National Guidelines for Stem Cell Research, to manufacture clinical-grade stem cells.
- Published more than 150 research articles and book chapters in journals of national and international repute, and have been granted 2 patents as well.
- Awarded by the International Society for Stem Cell Research, USA (Three times), received an NIH Fellowship to participate in the workshop on “Embryonic Stem Cell Culture” Univ. of Georgia, USA, entitled with AIIMS Excellence Award in recognition of notable published research work (2012, 2014 & 2015).
- Acknowledged by ICMR for an International Fellowship (2014- 2015) at the Kyoto Prefectural University of Medicine, Kyoto, Japan, in Stem Cells and Scaffolds.