Start
Jan 25, 2018 - 17:00
End
Jan 25, 2018 - 18:00
Venue
Rm. No. 118 Ground floor Chemical Engg. Dept.
Event Type
Speaker
Dr. Amol A. Kulkarni Chemical Engineering & Process Development Division CSIR-National Chemical Laboratory Pune
Title
Continuous Manufacturing: Connecting the dots of Flow Synthesis Reaction Engineering Design and Scale-up
Abstract: The specialty chemicals and pharmaceutical industry is conventionally (and almost entirely) based on the use of batch operations. Although batch or semi-batch processing offers some advantages because of the experience and familiarity it has several disadvantages such as inconsistent performance (viz. product quality yield selectivity etc.) significantly lengthy operations high utility consumption large footprint large inventory unsteady operations and so on. The advent of continuous flow synthesis for small (gm/day) to medium scale (1 – 100 kg/day) operations is an important milestone in the processing of high value chemicals intermediates products and formulations. Small volume continuous flow reactors have been making foot-fall in the pilot and manufacturing scales over last decade. The batch to continuous transformation needs systematic approach. While it saves time for taking a product from lab to market it demands certain scalability analysis that helps chemical engineers to understand the chemistry and chemists to keep some engineering principles in mind during its development. The approach that largely uses classical chemical reaction engineering for understanding (i) single step organic chemistry reactions (ii) multistep flow synthesis and (ii) synthesis of functional nanomaterials can be used for design of new reactor concepts for efficient production of valuable chemicals. While evolving and applying the approach various interesting problems that arise from the coupling of reaction engineering with fluid dynamics for single phase and multiphase reactions. Here a few case studies will be presented along with important challenges that chemical engineers have to resolve for translating the laboratory scale synthesis (of intermediates for dyes APIs agrochemicals and nanomaterials for conducting inks and touch screen applications) to their continuous manufacturing.Bio-sketch: Dr. Amol Kulkarni is a scientist at the CSIR-National Chemical Laboratory Pune. He has done his bachelors masters and PhD all from Chemical Engg. Dept. of Institute of Chemical Technology (ICT) at Mumbai. Subsequently he was a visiting research fellow at MIT and Humboldt fellow at Max Plank Inst. Magdeburg. His research interests are in microreaction technology microfluidics flow visualization hydrodynamics of multiphase reactors and their design and scale-up. He has been endowed with many awards recent and most notable among them are Vasvik award and Swarnajayanti fellowship.