Start
Jul 26, 2018 - 17:00
End
Jul 26, 2018 - 18:00
Venue
Room 118 Chemical Engg Dept
Event Type
Speaker
rof Tanmay Lele University of Florida USA
Title
Mechanics of nuclear shaping
Abstract: Shaping the nucleus represents a particular challenge for the migrating cell because of its large size and resistance to deformation. We designed experiments in which cells migrate from 1-D fibronectin lines to 2-D fibronectin patterns to examine how nuclear shape evolves with changes in cell morphology during cell migration. We observed that nuclear shape only changes when there are dynamic changes in cell shape. Coupled with the observation that nuclei retain shape upon removal of the surrounding cell and that nuclear flattening correlates with cell spreading without requiring actomyosin activity we propose the concept that the nucleus is shaped by dynamic stresses transmitted from the moving cell boundary to the nucleus through friction in the intervening F-actin network. This model for nuclear shaping explains the observed relationship between the shape of the cell and the shape of the nucleus.Bio: Tanmay Lele is Charles A Stokes Professor of Chemical Engineering and Director of the Institute of Cell & Tissue Science and Engineering at the University of Florida. He holds a joint appointment in Anatomy and Cell Biology and Affiliate appointments in Biomedical Engineering and Mechanical Engineering. His research is in cell and nuclear mechanics and currently funded by the National Institutes of Health and the National Science Foundation.
This seminar is compulsory for students registered for course CL 702 or CL 704.