Prof Rajesh Dave's Talk

Start
Jan 20, 2025 - 17:00
End
Jan 20, 2025 - 18:00
Venue
Room No 112 ,Chemical Engineering Department Ground Floor
Speaker
Prof Rajesh Dave, Distinguished Visiting Professor
Title
Film Coating of Fine Particles for Taste Masking and Extended Release

Abstract: 

Our research focuses on developing fundamental understanding of particle properties and their interactions at the nano and micro scales, along with translating that knowhow to innovate powder based solid form products [1-39]. Recent work has specifically targeted pharmaceutical industry with a hope to satisfy unmet industry and patient needs. Unique contributions that will be discussed in this presentation include predictive property enhancements for fine powders, their blends, and compressed tablets through particle engineering, potentially enabling digital product design and manufacturing of high-quality, low-cost, smaller tablet products, as well as process understanding via multi-scale modeling. We have leveraged these recent fundamental advances to develop innovative processes and products spanning important areas such as; overcoming the difficulties in processing pharmaceutical powders due to their high cohesion via solventless mechanical coating of nanoparticles on their surfaces; use of modeling tools for enhanced process and product understanding; and improved bioavailability of poorly water-soluble drugs. Highlights of the first one of these topics will be presented including recent advances uncovering the role of fine particle agglomeration on powder behavior and power-law relationship between agglomeration, flowability, and packing where the granular Bond number could be used as a dimensionless scaling parameter. The synergistic enhancements in the blend or formulation properties will be highlighted including blend uniformity, flowability, compaction properties, and enhanced capability for direct blend direct compaction (DB-DC) tableting at either high or very low drug loadings. 

 

Biography:

Prof. Rajesh Davé Fellow of the American Institute of Chemical Engineers (AIChE), American Association of Pharmaceutical Scientists (AAPS), and National Academy of Inventors (NAI) is a Distinguished Professor of Chemical and Materials Engineering at New Jersey Institute of Technology (NJIT).  He has granted 38 PhDs to his students, seven of those have been placed in US academia. His research contributions include 200+ journal papers (16,400+ Google citations, H-Index 68), and 23 issued patents. He has received numerous awards, including 2022 American Institute of Chemical Engineering (AIChE) PD2M Award for Outstanding Contribution to QbD for Drug Product, 2016 Thomas Alva Edison Patent Award, and 2015 AIChE Particle Technology Forum Fluidization Lectureship. He is currently the U.S. Executive Editor of Advanced Powder Technology, and the Past Chair of the AAPS Manufacturing Science and Engineering Community (MSE)