Start
Nov 28, 2013 - 11:00
End
Nov 28, 2013 - 12:00
Venue
Creativity Hall (Room 118) Chemical Engineering
Event Type
Speaker
Madhu Chetty Associate Professor Gippsland School of Information Technology Monash University.
Title
S-system modelling for reconstructing gene regulatory network
Abstract: S-system model is a set of non-linear differential equations possessing a rich structure capable of capturing various dynamics occurring in gene regulatory network (GRN). In this talk we discuss developing new evolutionary algorithms (EAs) for efficiently optimising the S-system model parameters. The EA performance is further improved by making cardinality of regulatory genes adaptive during optimisation. We further present enhancement of the existing S-system model to allow simultaneous implementation of instantaneous or time-delayed genetic interactions - leading to a Time-Delayed S-System (TDSS) model. Further techniques to make S-system model suitable for large scale implementation of genetic network will be discussed.Bio: A/Prof Madhu Chetty is with Monash University since 1995. At Monash initially he was with department of electrical and computer systems engineering Monash University but subsequently moved to Gippsland School of Information Technology. His research interests are in optimisation control and systems theory application for modelling and application of computational intelligence techniques to problems from life sciences (Systems Biology and Protein Structure Prediction). Currently his research group is working on modeling GRNs with focus on Cyanobacteria. A/Prof Chetty is also serving as associate editor of Elsevier’s Neurocomputing journal and Vice Chair of IAPR Technical Committee on Bioinformatics.