Start
Jul 04, 2017 - 16:00
End
Jul 04, 2017 - 17:00
Venue
Rm. No. 118 Ground floor Chemical Engg. Dept.
Event Type
Speaker
Dr. Pankaj Prasad Molecular Oncology lab at Department of Biological Sciences and Bioengineering IIT Kanpur.
Title
Hypoxia mediated epigenetic regulation of stemness in brain tumor
Abstract: Gliomas are known to be highly heterogenous tumors in their both genetic content as well as tumor microenvironment. Active DNA demetylation in the hypoxic interiors mediated by TET proteins appear to contribute to the cellular complexity and genomic instability associated with these difficult-to-treat and highly recurrent tumors. In recent times epigenetic regulators are being identified as drivers of oncogenesis and are being considered as therapeutic targets. During my Ph.D. I studied TET1 and 3 as mediators of pluripotent induction in hypoxic cells thereby suggesting their therapeutic relevance in effectively controlling the dedifferentiation of cancer cells in the hypoxic core of gliomas. I would talk about the involvement of epigenetic modifications mediated by TET in regulating master transcription factors that maintain pluripotent in GBM hypoxia.Bio: Dr. Pankaj Prasad did his graduation in Genetics from Bangalore University. He completed certificate course in Genetic Engineering from St. Joseph's College Bangalore. Then he joined M.Sc. programme at Department of Molecular and Human Genetics Banaras Hindu University. During his M.Sc. thesis work he studied the localization of 8-oxo-guanine in gall bladder carcinoma patients. Later he joined Department of Genetics University of Delhi South Campus to pursue my PhD where he studied the epigenetic regulation of stemness in brain tumour cells. Currently he is working as a project scientist in Molecular Oncology lab at Department o Biological Sciences and Bioengineering IIT Kanpur where he is studying the transcriptional regulation of SPINK1 in prostate cancer.