Start
Apr 30, 2014 - 12:00
End
Apr 30, 2014 - 13:00
Venue
Nano-Cure for Neuro-AIDS and drug addiction
Event Type
Speaker
Dr Madhavan Nair Professor and Founding Chair Dept. of Immunology Director Institute of Neuro- ImmunePharmacology FIU College of Medicine Associate Dean Bio. Med. Res Florida International University
ABSTRACT : Nano-Cure for Neuro-AIDS and drug addiction Although highly active anti-retroviral therapy (HAART) has resulted in remarkable decline in the morbidity and mortality in AIDS patients inadequately low delivery of anti-retroviral drugs across the blood–brain barrier (BBB) results in virus persistence. Opiates act synergistically with HIV-1 to potentiate the HIV-related neurotoxicity that leads to development of Neuro-AIDS. We herein report the development of a Magneto-Electric Nanocarrier (MEN) to deliver the drugs and demonstrate on-demand release of AZTTP by applying a low alternating current magnetic field. Owing to the intrinsic magnetoelectricity these nanoparticles can couple external magnetic fields with the electric forces in drug–carrier bonds to enable remotely controlled delivery without exploiting heat. Functional and structural integrity of the drug after the release was confirmed in in vitro experiments with human immunodeficiency virus-infected cells. The proposed nanocarrier is anticipated to simultaneously reduce NeuroAIDS and opiate addiction in HIV-1 infected subjects who are opiate users.