Dr. Himansu Sekhar Nanda's Talk

Mar 13, 2019 - 17:00

Mar 13, 2019 - 18:00

HOD conference room, Chemical Engg Dept

Seminars

Dr. Himansu Sekhar Nanda, IIITDM Jabalpur

Abstract:Biomedical micro and nanotechnology have attracted a wide range of materials and nanostructures for their potential application in regenerative therapies, drug delivery, tissue mending and so on. Among those, biomaterials such as porous scaffolds and surgical tissue glues (bioadhesives), novel nanomedicines have shown highest clinical importance in the field. In this talk, I will cover some of our recent developments and challenges in the field. The overall structure of the talk will follow few subheadings. 1. Porous scaffolds are exclusively used in tissue regeneration. However, the creation and control over the pore structure and interconnected pores in scaffold design remains a challenge. The use of an unique nontoxic porogen (i.e. ice microparticulates) to design and develop few porous and interconnected scaffolds of controlled pore structure will be discussed. In addition, integration of controlled release function, using appropriate drug delivery platform has shown promising results for future clinical application. 2. In vitro screening of novel nanomedicines relies on cytotoxic assays on established cancer cell lines grown on an appropriate tumor model mimicking the original complexity and heterogeneity of a clinical tumor. The design and development of a new generation hybrid scaffold for screening of a typical redox nanomedicine (functionalized nanoceria) will be discussed. Such new generation scaffolds may offer new opportunities in reconstructive surgery. 3. Clinical grade bioadhesives or medical glue offers a new route in addressing unmet surgical challenges in tissue fixation. Our recent development, pre-clinical applications (tissue mending and dynamic drug delivery) and challenges of few novel bioadhesive formulations prepared by grafting carbene precursors (Bromo-diazirine) on to the backbone of 5th generation (G5) Polyamidoamine (PAMAM) and poly caprolactone triol (PCLT) will be discussed. Bio: Dr. Nanda received his Ph. D in Materials Science and Engineering, majoring in Biomaterials from international graduate school of prestigious National Institute for Materials Science (NIMS), Japan. He holds the background of B-Tech in Biotechnology (BPUT Odisha) and M-Tech in Nanotechnology (IIT Roorkee). He was a post-doctoral fellow in King Abdullah University of Science and Technology (Oct 2014- Jan 2016) and a research fellow at Nanyang Technological University Singapore (Feb 2016-Sept 2017). From Oct 2017, he is working as an Assistant Professor at Department of Mechanical Engineering, Indian Institute of Information Technology Design and Manufacturing (IIITDM), Jabalpur. He is also visiting professor in College of Materials Science and engineering, Beijing University of Chemical Technology (BUCT) and Sate Key Lab of Molecular Engineering of Polymers, Fudan University, China. His major research interests include design and development of biomaterials (new generation porous scaffolds) for regenerative therapies, Bioadhesives for soft tissue sealing and dynamic drug release. He is also interested in nanomedicines for angiogenesis and cancer, adhesive based hydrogel coatings for medical implants and devices and biomechanics at implant-tissue interface.