Intrinsically disordered proteins (IDPs) are special proteins without a fixed 3D shape, like wiggly strings that flex to do key jobs in cells, but in diseases like Parkinson's (alpha-synuclein) or Alzheimer's (tau), mutations make them clump into toxic tangles harming brain cells. This project uses molecular dynamics (MD) simulations—computer models that mimic atomic wiggles over time—to watch how these changes spread along the protein chain, spotting "switches" that trigger clumping.

Intrinsically disordered proteins are proteins that lack a stable three dimensional structure. In many cases they control vital cellular processes or have been associated with disease. In this project, we use computer simulations to study a protein called IAPP that clumps up harmfully in type 2 diabetes, killing the cells that make insulin. Lacking fixed structure, IAPP's flexible conformations shift with mutations toward fibril-prone states that block insulin from working properly.

BTP
Developing an understanding the effect of microplastics on cellular function is important. This project will involve preparing microplastics from common commercial polymers (such as polyethylene, polypropylene, polystyrene and polyesters) and their thorough characterization. One aspect of this project will be to come up with a protocol to generate fluorescently tagged microplastics to allow them to be tracked as they are ingested by cells. Subsequently, cells will be exposed to these microplastics and their response will be studied.

About the project: