Intrinsically disordered proteins (IDPs) are special proteins without a fixed 3D shape, like wiggly strings that flex to do key jobs in cells, but in diseases like Parkinson's (alpha-synuclein) or Alzheimer's (tau), mutations make them clump into toxic tangles harming brain cells. This project uses molecular dynamics (MD) simulations—computer models that mimic atomic wiggles over time—to watch how these changes spread along the protein chain, spotting "switches" that trigger clumping. By revealing safe shapes versus harmful ones, our simulations guide new drugs to keep IDPs flexible and helpful, fighting neurodegeneration. 

Specific skill set: interest in biomolecular modelling and simulations, interest in coding

(Computational)