Venkatesh Lab

Sumana Srinivasan

Sumana Srinivasan

 

Education

PhD, Indian Institute pf Technology Bombay (December 2010)

M.S. (Computer Science and Engineering), Syracuse University, NY, USA (1992)

B.E. (Computer Science and Engineering), University of Mysore (1989)

 

Email

sumanas at ittb dot ac dot in

srisumana at gmail dot com

 



Research Summary

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Metabolism is fundamental for existence since it produces energy and synthesizes essential molecules of life. It is highly regulated and patterns in metabolic pathways have been conserved over evolution. A cell’s response to environmental stimuli is governed by the coordinated action of three important components, namely, signaling, gene expression and metabolic reactions. Hence, it is important to understand how an organism's genotype can be bridged to a specific phenotype along with the underlying molecular mechanisms. In the last decade, several formalisms have been developed to model the individual subsystems. However, integrated models that combine all the three into a coherent whole have been uncommon and the construction and analysis of such models pose several challenges. The usefulness of such integrated models is enormous as they help us understand cellular behavior under different environmental conditions as well as perturbations and enable us to map genotype to phenotype. Further, the models help us generate hypotheses that can be experimentally validated.

The main objective of our research is “Quantification, analysis and experimental validation of an integrated model comprising of signaling, gene expression and metabolic pathways, taking into consideration different control mechanisms and underlying mechanistic details enabling genotype-phenotype mappings for specific metabolic phenotypes under different environmental conditions in Escherichia coli". With this, we aim to understand the exact mechanism of how the genotype translates to a particular metabolic phenotype under different environmental stimuli. We also hope to glean evolutionary insights of how control mechanisms have evolved in nature and the criteria for selection.

A complete research statement can be found here.

 

PUBLICATIONS

 

Journals

  • Steady State Analysis of Genetic Regulatory Network incorporating underlying Molecular Mechanisms for Anaerobic Metabolism in Escherichia coli, Sumana Srinivasan and K. V. Venkatesh, Molecular Biosystems, 2014, 10, 562-575, Impact Factor 3.35
  • A Survey of Sensory Data Boundary Estimation, Covering and Tracking Techniques using Collaborating Sensors, Sumana Srinivasan, Subhasri Dattagupta, Purushottam Kulkarni and Krithi Ramamritham, Pervasive and Mobile Computing, vol. 8, Issue 3, June 2012, 358-375. (Cited by 6)

 

Conferences

  • ACE in the Hole - Adaptive Contour Estimation Using Collaborating Mobile Sensors, Sumana Srinivasan, Krithi Ramamritham and Purushottam Kulkarni, ACM International Conference on Information Processing in Sensor Networks 2008, St. Louis, Missouri, USA (Cited by 26)
  • Contour Estimation Using Mobile Sensors, Sumana Srinivasan and Krithi Ramamritham, 2nd ACM/SIGMOBILE Workshop on Dependability Issues in Wireless Ad Hoc Networks and Sensor Networks, MOBICOM 2006, Los Angeles (Cited by 17)
  • Passage Scoring for Question Answering via Bayesian Inference on Lexical Relations, Deepa Paranjpe, Ganesh Ramakrishnan, Sumana Srinivasan, TREC 2003: 305-210 (Cited by 13)
  • Resolving citations in a paper repository,Sunita Sarawagi, V. G. Vinod Vydiswaran, Sumana Srinivasan, Kapil Bhudhia, SIGKDD Explorations 5(2): 156-157 (2003) (Cited by 10)
  • A Shared Memory Programming Environment for Distributed Systems, UmeshBellur and Sumana Srinivasan, Proceedings of OpenForum `92 Technical Conference, Utrecht, The Netherlands, 1992.

 

Citations

http://scholar.google.co.in/citations?hl=en&user=24HLsbMAAAAJ

 

GRANTS

  • Genomic scale systemic modeling of gene regulatory networks, metabolic and signaling pathways for a specified phenotype and experimental validation (DST No. SR/S3/CE/040/2012:as a Co-PI along with PI Dr. K.V.Venkatesh)
  • Genomic scale modeling of gene regulatory networks cross-linking metabolic and signaling pathways for a specified phenotype (DST No. SR/WOS-A/ET-73/2011 as a PI along with mentor Dr. K.V.Venkatesh)

 

AWARDS and FELLOWSHIPS

  • University Rank Certificate, University of Mysore, Mysore (1989).
  • Research Assistantship, CASE Center, Syracuse University, NY, USA. (1991-92)
  • Institute Fellowship, Indian Institute of Technology Bombay, Mumbai (2004-2010)
  • DST Women Scientist Fellowship (2011-2014)