Education
PhD, Indian Institute pf Technology Bombay (December 2010)
M.S. (Computer Science and Engineering), Syracuse University, NY, USA (1992)
B.E. (Computer Science and Engineering), University of Mysore (1989)
sumanas at ittb dot ac dot in
srisumana at gmail dot com
Metabolism is fundamental for existence since it produces energy and synthesizes essential molecules of life. It is highly regulated and patterns in metabolic pathways have been conserved over evolution. A cell’s response to environmental stimuli is governed by the coordinated action of three important components, namely, signaling, gene expression and metabolic reactions. Hence, it is important to understand how an organism's genotype can be bridged to a specific phenotype along with the underlying molecular mechanisms. In the last decade, several formalisms have been developed to model the individual subsystems. However, integrated models that combine all the three into a coherent whole have been uncommon and the construction and analysis of such models pose several challenges. The usefulness of such integrated models is enormous as they help us understand cellular behavior under different environmental conditions as well as perturbations and enable us to map genotype to phenotype. Further, the models help us generate hypotheses that can be experimentally validated. The main objective of our research is “Quantification, analysis and experimental validation of an integrated model comprising of signaling, gene expression and metabolic pathways, taking into consideration different control mechanisms and underlying mechanistic details enabling genotype-phenotype mappings for specific metabolic phenotypes under different environmental conditions in Escherichia coli". With this, we aim to understand the exact mechanism of how the genotype translates to a particular metabolic phenotype under different environmental stimuli. We also hope to glean evolutionary insights of how control mechanisms have evolved in nature and the criteria for selection. A complete research statement can be found here. Journals http://scholar.google.co.in/citations?hl=en&user=24HLsbMAAAAJ Research Summary
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