BTP Topic

Nanosecond pulsed electric fields (nsPEFs) are promising for neural stimulation, but a single short pulse often requires a very high electric field. Such high fields can damage the cell membrane.

Recent experiments have shown that grouping nsPEFs into high-frequency, sub-megahertz or megahertz bursts can excite neurons at much lower electric-field strengths. This effect is thought to arise from the accumulation of small membrane-potential changes produced by successive pulses. However, the mathematical basis of this process and the role of burst parameters—such as pulse duration, repetition rate, duty cycle, and burst length—are not fully understood.

This project will develop mathematical models of nsPEF burst stimulation and use neuron-model simulations to study MHz compression. The aim is to identify stimulus conditions that produce efficient neuronal excitation while reducing the risk of membrane damage. MATLAB proficiency is helpful but not essential.