Speaker Name: Prof. K. V. Venkatesh 

Date: 04-02-2026 (Wednesday)

Time: 2:30 PM

Venue: LC102

Abstract: Human physiology is an ensemble of various biological processes spanning from intracellular molecular interactions to the whole-body phenotypic response. Systems biology endures to decipher these multi-scale biological networks and bridge the link between genotype to phenotype. The structure and dynamic properties of these networks are responsible for controlling and deciding the phenotypic state of a cell. Several cells and various tissues coordinate together to generate an organ level response which further regulates the ultimate physiological state. The overall network embeds a hierarchical regulatory structure, which when unusually perturbed can lead to undesirable pathophysiological state. At MetFlux, we have developed an Investigative Physiology Platform for specific states which integrates several data types from genomic to metabalomics to diagnostic biomarkers. Two use cases have been aligned using the Investigative Physiology platform, one for RnD support in drug discovery pipeline and another for precision health among individuals. In RnD, the platform is tuned to provide end-to-end support from data analysis, and target identification to formulation optimisation, in silico clinical study and clinical study protocol optimisation. The application of is illustrated in the case of metabolic and immune disorders. Further, the platform is also used to develop physiological benchmarking among individuals by ingesting diverse data types and to provide personalised intervention suggestion. The work emphasises the importance of integrating data structures, knowledge graphs, expert systems through a software architecture to physiological readouts, digitally linking various data types providing a scientific basis for personalised nutrition and lifestyle suggestions.