Prof. Sharad Bhartiya Research Group IIT Bombay

GAL System

GAL System (with Prof. K. V. Venkatesh)

The GAL system in yeasts Saccharomyces cerevisiae has evolved to utilize galactose as an alternative carbon and energy source, in the absence of glucose. We have developed a dynamic model of the GAL system and linked it with growth. The developed model predicts the importance of nucleocytoplasmic shuttling and autoregulation of regulatory gene GAL80 as noted in literature. The model also captures the experimental observation that in absence of galactose, GAL3 oversynthesis can induce the GAL system. The work will also identify the relationship between the regulatory motifs of the GAL system in different yeasts and the niche that each of the designs provides to the organisms.