Prof. Sharad Bhartiya Research Group IIT Bombay

The near-integrating control behaviour in osmoadaptation in yeast

The near-integrating control behaviour in osmoadaptation in yeast (with Prof. K.V. Venkatesh): The osmoadaptation system in yeast upregulates the HOG pathway as a means of mediating osmotic shock. The HOG system in turn turns on glycerol synthesis, an osmolyte, that helps the cell to recover its volume and can subsequently resume cellular functions. The recovery of the cell volume is achieved through a near-integrating regulation strategy. This work delineates the existence of the near-integrator in the overall osmotic response system