Pancreas on a chip to understand nanoparticle mediated drug delivery for killing of pancreatic cancer-cells
Pancreatic cancer is one of the cancers having the lowest 5-year survival rate, because of its late diagnosis and availability of only a couple of known drugs with very moderate increase in patient’s survival. Based on our earlier work, we have shown that, nanoparticle mediated delivery of existing drugs can enhance the cytotoxicity in cancer cells. Accordingly, we have developed subcutaneous and orthotopic in-vivo experiments in mouse, in collaboration with Advanced Cancer Teaching Research and Education Centre (ACTREC), Navi Mumbai.
The aim of this project will be to further increase the efficacy of this process, by constructing both 3D printed polymer-based, and photolithography-based silicon wafer chips, in order to mimic the interaction of nanoparticles with cancer cells in a controlled microfluidic environment. The resulting insight will elucidate the optimization of the nanoparticle-based drug delivery system.