Drug Delivery

Development of a microfluidic based placenta-on-chip for application in pregnancy related disorders

Maternal and child health is a priority plan of the government of India and reducing maternal and neonatal mortality rates takes the top precedence in achieving this goal. Presently, India has a high burden of pregnancy-related complications like preeclampsia and gestational diabetes that lead to feto- maternal morbidity and mortality. While in many instances the causes of these disorders are unknown, placental dysfunction is a common feature observed in most conditions.  read more »

Proposing Faculty
Research Area
  • Biomaterials
  • Drug Delivery

Simulation of Electroporation process using Dissipative particle dynamics for cancer treatment

Electroporation involves punching of holes of the size of few 10s of nanometers into bilayer membranes to put across
polar drugs (often used in chemotherapy) such as bleomycin and cisplatin for anti-cancer treatment. The long time and
length scales associated with the pores merits a meso-scopic method such as Dissipative particle dynamics. With an exclusive aim to looking into a mechanism of membrane electroporation on mesoscopic
length and time scales, we recently reported the dissipative particle dynamics (DPD) simulation results for  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomaterials
  • Drug Delivery
  • Molecular Simulations
  • Statistical Themodynamics
  • Surface Science

Aerosol synthesis of insulin containing nanoparticles for inhalation delivery

co-guide: Y.S. Mayya  read more »

Proposing Faculty
Research Area
  • Biomaterials
  • Drug Delivery
  • Nano-composites
  • Nanoparticles
Venkat Gundabala

A Method and an Apparatus for Synthesizing Vesicles by Interdiffusion of Stationary Phases

The present invention relates to a method and an apparatus for synthesizing stable uni-lamellar vesicles (liposomes) for drug delivery and similar applications. The main advantage over existing methods is the ability to produce in a single step, stable liposomes of a mono-disperse population in the size range of 200-5000nm controlled by temperature and lipid type alone, without subjecting to harsh environments and with negligible external energy supplied. The method of the present invention is simple, feasible and inexpensive for the large-scale production of liposomes.

Mini Extruder(Avanti Polar Lipids Inc. )

thin film extruder.jpg

The Avanti Mini-Extruder allows the preparation of small unilamellar vesicles from different lipid species by extrusion. The heating block allows the extrusion of unilamellar vesicles at elevated temperatures, which is critical for the successful production of vesicles from phospholipids with a phase transition temperature (Tm) above room temperature.

Web links:
http://www.avantilipids.com/index.php?option=com_content&view=article&id...
http://www.avantilipids.com/index.php?option=com_content&view=article&id...

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Molecular Modelling Software

Materials Studio is a comprehensive materials modeling and simulation application designed for scientists in chemicals and materials R&D as well as pharmaceuticals development. Materials Studio reduces the time needed to solve complex calculations with:
• Industry-leading graphical user environments
• State-of-the-art simulation technology from quantum to atomistic to mesoscale
• Powerful statistical tools for structure-property relationships  read more »

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High Speed Camera

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Model V12.1, PHANTOM, Vision Research, AMETEK

Captures images @ 6242 frames per second at full 1280 x 800 widescreen resolution and 1,000,000 pictures-per-second at reduced resolution. The camera supports 8- and 12-bit pixel depth. Equipped with Phantom Software and a Cinemag interface.

Additional accessories include image-based auto-trigger, an internal mechanical shutter for remote/automatic CSRs, Canon EOS lens mount.

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Microforge-Grinding Center

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Model details: MFG-5 Microforge-Grinding Center, MDI Micro Data instruments , Inc., USA
Description:  read more »

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Micromanipulator

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Model details: Three-axis water hydraulic micromanipulator, MHW-3, Narishige Co.Ltd. Japan
Description:
This instrument facilitates precise maneuvering of samples under microscope.

Applications:

For patch clamping experiments to study of single or multiple ion channels in cells.
Attachments available:
B-9 Ball joint. This highly stable ball joint was developed for patch clamping. Allows free rotation and approach from many different angles.  read more »

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