Biomolecular Engineering

Targeting transcriptional regulators in drug resistant bacteria

In this project we will employ the CRISPR technique to target transcriptional regulators in resistant bacteria in an attempt to regulate their sensitivity towards drugs. Key regulators to be targetted would be identified using a comnputational approach.

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Systems Biology

Single-cell data guided modeling of phenotype switching

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Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Data Analysis
  • Identification
  • Modelling
  • Optimisation
  • Reaction Engineering
  • Systems Biology

Phenotype switching during Tumor Necrosis Factor alpha signaling

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Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Systems Biology

Topic 3: Development of synthetic biology tools for cyanobacteria.

Guide:  Prof. Pramod Wangikar.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Data Analysis
  • Modelling
  • Optimisation
  • Systems Biology

Topic 2: Non-stationary 13C-Metabolic flux analysis of non-model organisms.

Guide:  Prof. Pramod Wangikar.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Modelling
  • Systems Biology

Theoretical models to understand evolutionary processes.

In the story of evolution from a single cell (LUCA: https://en.wikipedia.org/wiki/Last_universal_common_ancestor) to complex eukaryotes, there are several missing links. In this project, we aim to develop theoretical and computational models to analyze these missing aspects in our understanding of evolution of life on Earth.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Enzymology
  • Systems Biology

Modeling and simulation of endoplasmic reticulum stress pathways (TA/FA)

Endoplasmic reticulum (ER) is responsible for many important cellular functions such as
folding of proteins, glycosylation and quality control etc. Many
environmental and genetic perturbations such as hypoxia, glucose deficiency, overload of unfolded protein can lead to ER stress. ER stress has been associated with pathogenesis of many diseases
such as diabetes, neurodegenarative diseases such as Alziemers and
Parkinsons. Further, industrial recombinant mammalian cell lines producting recombinant therapeutics are also subject to ER stress.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Systems Biology

Genomic study of antibiotic resistance mechanisms (TA/FA)

Antibiotics have been critical for the dramatic rise of life expectancy and the fight against many diseases and infections in the past fifty years. However, over the past decade, antimicrobial resistance has emerged as a major public-health crisis. We are using Streptomyces coelicolor and Mycobacterium smegmatis as models to decipher the various mechanisms employed by bacteria to counter antibiotics. A transcriptomic study using whole-genome microarrays revealed a combination of mechanisms that Streptomyces uses to counter fluoroquinolones.  read more »

Proposing Faculty
Research Area
  • Biomolecular Engineering
  • Systems Biology
Supreet Saini
Ganesh A Viswanathan