Biochemical Engineering

Topic 4: Metabolic engineering of methanotrophs for the production of liquid fuels from biogas

Guide:  Prof. Pramod Wangikar.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Modelling
  • Optimisation
  • Systems Biology

Topic 3: Development of synthetic biology tools for cyanobacteria.

Guide:  Prof. Pramod Wangikar.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Data Analysis
  • Modelling
  • Optimisation
  • Systems Biology

Topic 2: Non-stationary 13C-Metabolic flux analysis of non-model organisms.

Guide:  Prof. Pramod Wangikar.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Modelling
  • Systems Biology

Topic 1. Development of efficient bioprocesses for the production, purification and PEGylation of therapeutic proteins

 read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Modelling
  • Optimisation

Simulation of Electroporation process using Dissipative particle dynamics for cancer treatment

Electroporation involves punching of holes of the size of few 10s of nanometers into bilayer membranes to put across
polar drugs (often used in chemotherapy) such as bleomycin and cisplatin for anti-cancer treatment. The long time and
length scales associated with the pores merits a meso-scopic method such as Dissipative particle dynamics. With an exclusive aim to looking into a mechanism of membrane electroporation on mesoscopic
length and time scales, we recently reported the dissipative particle dynamics (DPD) simulation results for  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomaterials
  • Drug Delivery
  • Molecular Simulations
  • Statistical Themodynamics
  • Surface Science

Simulation of blood flow through capillaries

The simulation of blood flow through capillaries is critical to understanding the origin as well as implications of various diseases in humans. Blood is constituted of different cells, such as Erythrocytes and Leucocytes, The project will involve simulating whole blood, with resolved blood cells using three dimensional boundary integral method. Our group has recently looked at compound vesicles in shear flow as well as Red Blood cells in electric fields.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Computational Flow Modelling (CFD)
  • Electrohydrodynamics
  • Fluid Mechanics and Stability

Theoretical models to understand evolutionary processes.

In the story of evolution from a single cell (LUCA: https://en.wikipedia.org/wiki/Last_universal_common_ancestor) to complex eukaryotes, there are several missing links. In this project, we aim to develop theoretical and computational models to analyze these missing aspects in our understanding of evolution of life on Earth.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Enzymology
  • Systems Biology

Bioprocess development for production of biosimilars (TA/FA)

Chinese hamster ovary cells are the workhorses for the production of recombinant therapeutics such as monoclonal antibodies. The Biosimilars market is fast expanding in India. This project will develop process strategies include chemically defined media and fed-batch/perfusion platforms to obtain high yields and product quality of model biosimilars.

Proposing Faculty
Research Area
  • Biochemical Engineering

Modeling and simulation of endoplasmic reticulum stress pathways (TA/FA)

Endoplasmic reticulum (ER) is responsible for many important cellular functions such as
folding of proteins, glycosylation and quality control etc. Many
environmental and genetic perturbations such as hypoxia, glucose deficiency, overload of unfolded protein can lead to ER stress. ER stress has been associated with pathogenesis of many diseases
such as diabetes, neurodegenarative diseases such as Alziemers and
Parkinsons. Further, industrial recombinant mammalian cell lines producting recombinant therapeutics are also subject to ER stress.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Systems Biology

Nanomedicines: physico-chemical and biological studies

Nanomedicines are based on nanoparticles and other nanostructures. They have become important in drug delivery in recent times, so they find increasing use in modern medicinal systems. But also important are nanoparticles, nanostructures and nanocrystals in traditional and alternative medicinal systems, which our group has been studying with modern tools of nanotechnology and biology. The aim of this project is to characterise and propose mechanism of action of such nanomedicines by physical, chemical and biological techniques like TEM, SEM, DLS, PCR, cell culture, and the like.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomaterials