Biochemical Engineering

Targeting transcriptional regulators in drug resistant bacteria

In this project we will employ the CRISPR technique to target transcriptional regulators in resistant bacteria in an attempt to regulate their sensitivity towards drugs. Key regulators to be targetted would be identified using a comnputational approach.

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Systems Biology

Single-cell data guided modeling of phenotype switching

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Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Data Analysis
  • Identification
  • Modelling
  • Optimisation
  • Reaction Engineering
  • Systems Biology

Phenotype switching during Tumor Necrosis Factor alpha signaling

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Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Systems Biology

Biocatalytic microreactors

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Proposing Faculty
Research Area
  • Biochemical Engineering
  • Catalysis
  • Process Control
  • Reaction Engineering
  • Reactor Modelling

Topic 3: Development of synthetic biology tools for cyanobacteria.

Guide:  Prof. Pramod Wangikar.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Data Analysis
  • Modelling
  • Optimisation
  • Systems Biology

Topic 2: Non-stationary 13C-Metabolic flux analysis of non-model organisms.

Guide:  Prof. Pramod Wangikar.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Modelling
  • Systems Biology

Simulation of Electroporation process using Dissipative particle dynamics for cancer treatment

Electroporation involves punching of holes of the size of few 10s of nanometers into bilayer membranes to put across
polar drugs (often used in chemotherapy) such as bleomycin and cisplatin for anti-cancer treatment. The long time and
length scales associated with the pores merits a meso-scopic method such as Dissipative particle dynamics. With an exclusive aim to looking into a mechanism of membrane electroporation on mesoscopic
length and time scales, we recently reported the dissipative particle dynamics (DPD) simulation results for  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomaterials
  • Drug Delivery
  • Molecular Simulations
  • Statistical Themodynamics
  • Surface Science

Simulation of blood flow through capillaries

The simulation of blood flow through capillaries is critical to understanding the origin as well as implications of various diseases in humans. Blood is constituted of different cells, such as Erythrocytes and Leucocytes, The project will involve simulating whole blood, with resolved blood cells using three dimensional boundary integral method. Our group has recently looked at compound vesicles in shear flow as well as Red Blood cells in electric fields.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Computational Flow Modelling (CFD)
  • Electrohydrodynamics
  • Fluid Mechanics and Stability

Theoretical models to understand evolutionary processes.

In the story of evolution from a single cell (LUCA: https://en.wikipedia.org/wiki/Last_universal_common_ancestor) to complex eukaryotes, there are several missing links. In this project, we aim to develop theoretical and computational models to analyze these missing aspects in our understanding of evolution of life on Earth.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Enzymology
  • Systems Biology

Bioprocess development for production of biosimilars (TA/FA)

Chinese hamster ovary cells are the workhorses for the production of recombinant therapeutics such as monoclonal antibodies. The Biosimilars market is fast expanding in India. This project will develop process strategies include chemically defined media and fed-batch/perfusion platforms to obtain high yields and product quality of model biosimilars.

Proposing Faculty
Research Area
  • Biochemical Engineering