Biochemical Engineering

Nanoparticle based systems and devices for drug delivery in cancer (TA or FA topic)

We have successfully synthesized different solid and porous nanoparticles in our laboratory with controlled pore size, high specific surface area and different surface properties. These particles have been loaded with different drugs, like, doxorubicin, gemcitabine, curcumin for cancer-treatment and rifampicin, isoniazid and norfloxacin for tuberculosis-treatment.  read more »

Proposing Faculty
Research Area
  • Adsorption
  • Biochemical Engineering
  • Biomaterials
  • Coatings
  • Colloids
  • Drug Delivery
  • Nano-composites
  • Nanoparticles
  • Surface Science

In vitro evolution to decipher the molecular mechanism of speciation in yeast

How does speciation take place? In this project, we aim to understand the mechanics and mechanisms of how does an ancestor diverge and give rise to two distinct species. This project involves working with yeast and theoretical modeling of evolutionary processes. [This project is in collaboration with Prof. PJ Bhat from BSBE, IITB]

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Systems Biology

Theoretical models to understand evolutionary processes.

In the story of evolution from a single cell (LUCA: https://en.wikipedia.org/wiki/Last_universal_common_ancestor) to complex eukaryotes, there are several missing links. In this project, we aim to develop theoretical and computational models to analyze these missing aspects in our understanding of evolution of life on Earth.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Enzymology
  • Systems Biology

Bioprocess development for production of biosimilars (TA/FA)

Chinese hamster ovary cells are the workhorses for the production of recombinant therapeutics such as monoclonal antibodies. The Biosimilars market is fast expanding in India. This project will develop process strategies include chemically defined media and fed-batch/perfusion platforms to obtain high yields and product quality of model biosimilars.

Proposing Faculty
Research Area
  • Biochemical Engineering

Non-stationary 13C Metabolic Flux Analysis of photosynthetic microorganisms.



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Proposing Faculty
Research Area
  • Biochemical Engineering
  • Computational Biology

Reaction network of the nodes in the vertex cover of the Tumor Necrosis Factor alpha signaling network (TA/FA)

Tumor necrosis factor alpha (TNFa), a pleitrophic cytokine that can trigger both apoptosis and cell proliferation/survival, is recently being considered for combination drug therapies for cancer treatment. Success of such attempts hinges on the holistic understanding of the ability of cells triggered with TNFa to respond with the apoptosis phenotype or the programmed cell-death on all cells in a population. Recently, the group has put together a manually curated, comprehensive TNFa signalling network.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Enzymology
  • Heat and Mass Transfer
  • Reaction Engineering
  • Reactor Modelling
  • Systems Biology

A new approach for cancer treatment: Apoptosis triggered by Tumor necrosis factor alpha (TA/FA)

Tumor necrosis factor alpha (TNFa), a pleitrophic cytokine that can trigger both apoptosis and cell proliferation/survival, is recently being considered for combination drug therapies for cancer treatment. Success of such attempts hinges on the holistic understanding of the ability of cells triggered with TNFa to respond with the apoptosis phenotype or the programmed cell-death on all cells in a population. Recently, the group has put together a manually curated, comprehensive TNFa signalling network.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Systems Biology

Host engineering of cyanobacteria and micro-algae for biofuel applications (TA/FA/TAP)





One of the major challenges faced in implementing
cell based processes includes identification of a suitable host strain followed
by application of several orthogonal engineering strategies to optimize the
cell. Thus, host engineering
broadly refers to developing a host cell chassis for the production of a class
of molecules.  This project is on host
engineering of photosynthetic organisms. We argue that only the local  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Systems Biology

Modeling and simulation of endoplasmic reticulum stress pathways (TA/FA)

Endoplasmic reticulum (ER) is responsible for many important cellular functions such as
folding of proteins, glycosylation and quality control etc. Many
environmental and genetic perturbations such as hypoxia, glucose deficiency, overload of unfolded protein can lead to ER stress. ER stress has been associated with pathogenesis of many diseases
such as diabetes, neurodegenarative diseases such as Alziemers and
Parkinsons. Further, industrial recombinant mammalian cell lines producting recombinant therapeutics are also subject to ER stress.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Computational Biology
  • Systems Biology

Nanomedicines: physico-chemical and biological studies

Nanomedicines are based on nanoparticles and other nanostructures. They have become important in drug delivery in recent times, so they find increasing use in modern medicinal systems. But also important are nanoparticles, nanostructures and nanocrystals in traditional and alternative medicinal systems, which our group has been studying with modern tools of nanotechnology and biology. The aim of this project is to characterise and propose mechanism of action of such nanomedicines by physical, chemical and biological techniques like TEM, SEM, DLS, PCR, cell culture, and the like.  read more »

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomaterials