Phenotype switching during Tumor Necrosis Factor alpha signaling

Tumor necrosis factor alpha, a pleiotropic cytokine capable of exhibiting pro-survival, apoptosis, or necroptotic phenotypes, is implicated in several cancers and rheumatoid arthritis. Since TNFa is present in ample quantities in the tumor microenvironment, use of the cytokine in combination with other targets is being considered as potential approach for combating such diseases. Achieving the desired apoptotic/necroptotic phenotype in all diseased cells during treatment is necessary for longer remission. The objective of the project is to understand what causes phenotype switching from pro-survival to apoptosis in a population of normally growing mammalian cells exposed to TNFa. The project is primarily experimental in nature.

Preferred background
: B.Tech/M.Tech/M.Sc Biotech or Life Sciences or equivalent.

Proposing Faculty
Research Area
  • Biochemical Engineering
  • Biomolecular Engineering
  • Systems Biology