Development of a microfluidic based placenta-on-chip for application in pregnancy related disorders

Maternal and child health is a priority plan of the government of India and reducing maternal and neonatal mortality rates takes the top precedence in achieving this goal. Presently, India has a high burden of pregnancy-related complications like preeclampsia and gestational diabetes that lead to feto- maternal morbidity and mortality. While in many instances the causes of these disorders are unknown, placental dysfunction is a common feature observed in most conditions.
Herein, we aim to develop a microfluidic-based placenta-on-chip that will mimic the spatial arrangement of the maternal-placental barrier and blood flow conditions.
The toxicity of the selected drugs on cell viability and placental permeability will be assessed.

Expected Pre-requisite: Prior experinece in microfbarication and microfludics.

The candidate must be enthusiastic to work at material-biology interface.

The candidate will be co-guided by Prof. Debjani Paul, BSBE.

Proposing Faculty
Research Area
  • Biomaterials
  • Drug Delivery