Aerosol synthesis of insulin containing nanoparticles for inhalation delivery

co-guide: Y.S. Mayya

Systemic delivery of insulin to diabetic patients via the pulmonary pathway, requires insulin to be
inhaled in the form of aerosolized particles. These particles should deposit in
the deep lung (or alveolar region) for efficient absorption into the blood stream, contain biocompatible excipients
and cater to basal needs of insulin, through controlled release. The method of making such nanoparticles should
also ensure the structural and functional integrity of active pharmaceutical
ingredient. In some cases, dry powder inhalation based insulin formulations may
give rise to cases of patient non-compliance by triggering coughing and other
obstructive bronchial disorders in the long term.
In this work, it is proposed to prepare insulin containing nanoparticles, using
a recently patented method of spray drying solution droplets generated from
air-jet atomization. The dried aerosol nanoparticles are directly transferred to liquid media to form stable aqueous
suspensions, through collection in a wet electrostatic precipitator. Nanoparticles
would contain insulin encapsulated in lipid or other excipients compatible with
the lung environment. Control of layered substructure will be done, with
guidance from simulations using a droplet drying model. Surface modification of
nanoparticles will be done to obtain highly stable nanoparticle suspensions
suitable for inhalation delivery. Non-aqueous suspensions in approved
propellants will be explored for inhalation delivery through pMDIs.


Proposing Faculty
Research Area
  • Biomaterials
  • Drug Delivery
  • Nano-composites
  • Nanoparticles